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Analysis of Reddit posts highlights symptoms reported by GLP-1 drug users

ScienceDaily reports that researchers examined 400,000 forum posts regarding experiences with semaglutide and tirzepatide.

Updated Sep 13, 2026 · 14:48 UTC1 reports

The short version

  • University of Pennsylvania researchers analyzed 400,000 Reddit posts from nearly 70,000 users spanning more than five years to catalog self-reported symptoms from GLP-1 medications.[ScienceDaily]
  • The analysis found that nearly 4 percent of users in the examined sample reported experiencing menstrual irregularities.[ScienceDaily]
  • Study authors emphasized that the observed social media patterns do not establish that the medications caused any of the reported issues.[ScienceDaily]

Key facts

  • Researchers at the University of Pennsylvania evaluated over 400,000 Reddit posts from nearly 70,000 users over five years.[ScienceDaily]
  • The study, published in Nature Health, tracked discussions covering medications such as semaglutide and tirzepatide.[ScienceDaily]
  • Almost 4 percent of users within the sampled discussions reported experiencing menstrual irregularities.[ScienceDaily]

What remains uncertain

  • The findings only show reported online associations and do not prove a direct causal relationship between the medications and the symptoms.[ScienceDaily]

Sources

Outlet counts describe coverage, not independent confirmation. Reports may share a wire service or original source.