Experimental DNA treatment cuts cholesterol in mice, study finds

The short version

• Scientists from the University of Barcelona and University of Oregon created a DNA-based therapy targeting the PCSK9 protein.[ScienceDaily]
• The experimental molecule HpE12 lowered cholesterol by 47% in transgenic mice after a single dose.[ScienceDaily]
• Researchers claim the approach avoids side effects linked to statins, but human trials are still required.[ScienceDaily]

Key facts

• Researchers at the University of Barcelona and the University of Oregon designed a DNA therapy targeting the PCSK9 protein.[ScienceDaily]
• The treatment uses polypurine hairpins to inhibit gene activity without relying on statins.[ScienceDaily]
• The HpE12 molecule reduced PCSK9 protein levels by 87% in cultured human liver cells.[ScienceDaily]
• A single injection of HpE12 decreased cholesterol levels by 47% in transgenic mice within three days.[ScienceDaily]

Sources

Outlet counts describe coverage, not independent confirmation. Reports may share a wire service or original source.

• DNA treatment cuts bad cholesterol by nearly 50% without statinsScienceDaily - Health