Science
Researchers identify protein mechanism that limits nerve regeneration in mice
Blocking the protein AHR promoted axon regrowth and improved recovery in mouse models of nerve and spinal cord injuries.
The short version
- Mount Sinai researchers found that the protein aryl hydrocarbon receptor (AHR) limits nerve regrowth by prioritizing cellular stress response over rebuilding damaged axons.
- Suppressing or removing AHR in mouse models of spinal cord and peripheral nerve injuries enabled axon regeneration and restored movement and sensation.
- Because existing AHR-inhibiting drugs are already in clinical trials for other conditions, researchers hope to explore similar treatments for neural injuries.
Key facts
- Researchers at the Icahn School of Medicine at Mount Sinai published findings in Nature showing that the protein AHR acts as a brake on axon regeneration.[ScienceDaily]
- AHR normally supports protein quality control, or proteostasis, to help injured neurons withstand stress, which restricts the protein production needed to rebuild axons.[ScienceDaily]
- In mouse models with peripheral nerve damage and spinal cord injuries, blocking or removing AHR led to improved movement, sensation, and axonal regeneration.[ScienceDaily]
- Several AHR-inhibiting drugs are already being tested in clinical trials for other medical conditions.[ScienceDaily]
What remains uncertain
- Additional research is needed to determine appropriate treatment timing, dosage, effectiveness across different neural injuries, and safety in human patients.[ScienceDaily]
Sources
- Scientists discover why damaged nerves struggle to healScienceDaily - Science